Resource Type

Journal Article 1

Year

2016 1

Keywords

DNA alkylation 1

bioconjugation 1

quione methide 1

reversible covalent reaction 1

target-directed modification of nucleic acids 1

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DNA alkylation promoted by an electron-rich quinone methide intermediate

Chengyun Huang,Steven E. Rokita

Frontiers of Chemical Science and Engineering 2016, Volume 10, Issue 2,   Pages 213-221 doi: 10.1007/s11705-015-1541-3

Abstract: To enhance the rates of these processes, a new quinone methide precursor with an electron donating substituentAdditionally, this substituent has been placed to the nascent -methylene group of the quinone methide

Keywords： quione methide     DNA alkylation     reversible covalent reaction     bioconjugation     target-directed modification    

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DNA alkylation promoted by an electron-rich quinone methide intermediate

Chengyun Huang,Steven E. Rokita

Journal Article